Broadening and deepening or broadening versus deepening: The question of enlargement and Europe's 'hesistant Europeans'

The European Union sees the inclusion of many Eastern European states -enlargement- as a natural progression in the process of building an 'ever closer union'. For the European Commission in particular, the process of enlargement (broadening) is part of the process of integration and acts as a complement to the development of a stronger role for the European Union and its institutions or deepening of integration. Yet as the first Irish referendum on the Nice Treaty showed, not all of European's citizens see the two processes of enlargement and integration in the same light. This article addresses two related questions. First, how are attitudes towards deepening and broadening related, and do European citizens see them as complementary or contradictory? Second, and related to the first, what factors drive popular attitudes towards enlargement

Forecasting and Evaluating the Consequences of Electoral Change in New Zealand

The debate in New Zealand over whether to adopt a mixed-member proportional (MMP) system was based on a number of predictions about the effects of electoral systems. After four elections under MMP we are now in a better position to evaluate the validity of these claims. We find that both proponents and opponents made claims that proved to be true but there were also unforeseen consequences that neither side predicted

Perceptions of Electoral Fairness and Voter Turnout

Previous research has established a link between turnout and the extent to which voters are faced with a “meaningful” partisan choice in elections; this study extends the logic of this argument to perceptions of the “meaningfulness” of electoral conduct. It hypothesizes that perceptions of electoral integrity are positively related to turnout. The empirical analysis to test this hypothesis is based on aggregate-level data from 31 countries, combined with survey results from Module 1 of the Comparative Study of Electoral Systems survey project, which includes new and established democracies. Multilevel modeling is employed to control for a variety of individual- and election-level variables that have been found in previous research to influence turnout. The results of the analysis show that perceptions of electoral integrity are indeed positively associated with propensity to vote. </jats:p

C^2/Z_n Fractional branes and Monodromy

We construct geometric representatives for the C^2/Z_n fractional branes in terms of branes wrapping certain exceptional cycles of the resolution. In the process we use large radius and conifold-type monodromies, and also check some of the orbifold quantum symmetries. We find the explicit Seiberg-duality which connects our fractional branes to the ones given by the McKay correspondence. We also comment on the Harvey-Moore BPS algebras.Comment: 34 pages, v1 identical to v2, v3: typos fixed, discussion of Harvey-Moore BPS algebras update

Polynomial-Time Amoeba Neighborhood Membership and Faster Localized Solving

We derive efficient algorithms for coarse approximation of algebraic hypersurfaces, useful for estimating the distance between an input polynomial zero set and a given query point. Our methods work best on sparse polynomials of high degree (in any number of variables) but are nevertheless completely general. The underlying ideas, which we take the time to describe in an elementary way, come from tropical geometry. We thus reduce a hard algebraic problem to high-precision linear optimization, proving new upper and lower complexity estimates along the way.Comment: 15 pages, 9 figures. Submitted to a conference proceeding

Topological and geometrical restrictions, free-boundary problems and self-gravitating fluids

Let (P1) be certain elliptic free-boundary problem on a Riemannian manifold (M,g). In this paper we study the restrictions on the topology and geometry of the fibres (the level sets) of the solutions f to (P1). We give a technique based on certain remarkable property of the fibres (the analytic representation property) for going from the initial PDE to a global analytical characterization of the fibres (the equilibrium partition condition). We study this analytical characterization and obtain several topological and geometrical properties that the fibres of the solutions must possess, depending on the topology of M and the metric tensor g. We apply these results to the classical problem in physics of classifying the equilibrium shapes of both Newtonian and relativistic static self-gravitating fluids. We also suggest a relationship with the isometries of a Riemannian manifold.Comment: 36 pages. In this new version the analytic representation hypothesis is proved. Please address all correspondence to D. Peralta-Sala

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease